Zack is now at the one year point since his last puppy shot. I was somewhat surprised when the other day, I called his insurance company, PetCare, and asked if they accept titers instead of vaccination as evidence that the dog is adequately protected and was told yes, they accept titers.
I had titers measured and the results showed adequate titers for distemper and parvo. What I've read about duration of immunity research has convinced me that for these diseases, for most dogs, successful immunization is very long, or lifelong, so that i can feel safe when a titer shows evidence that his previous vaccinations were successful in immuizing him. In addition to the research citations nad reports I've seen, i had a personal consultation with Jean Dodds who has performed some of that research, and listened to her opinions, and as a result, i feel assured that Zack is very likely protected for a long time and probably for life. I will repeat the titers later to see if there's any trend toward them declining.
This is my personal decision, that further vaccination for parvo and distemper, given adequate titers, is unnecessary and thus exposes him to unnecessary risk, not just of acute adverse reactions but of long term chronic health risks. I'm particularly worried about long term autoimmune processes showing up later. So, i welcome information from credible sources showing that it takes less vaccination to achieve protection.
Here's what Zack's lab report from the Hemopet lab said, and this wording is typical of other labs, though labs will vary as to their reference values.
"Parvovirus Vaccine Titer (ELISA)
*Parvovirus (IgG) 1:80 ADEQUATE LEVEL Titer
An ELISA result correlated with an HI (hemagglutination-inhibiting)
antibody titer of greater than or equal to 1:80, indicates memory
response immunity. A result of less than 1:80 indicates a low
antibody response and inadequate memory response immunity.
Distemper Vaccine Titer (ELISA)
*Distemper (IgG) 1:16 ADEQUATE LEVEL TITER
An ELISA result correlated with an SVN (serum virus neutralization)
antibody titer of greater than or equal to 1:16, indicates memory
response immunity. A result of less than 1:16 indicates a low level
and inadequate memory response immunity.
Vaccine Titer Serology
Serologic/vaccine titers for parvovirus and distemper show
adequate/adequate humoral immunity indicating that this dog should
respond with a boosted anamnestic effect to afford memory reponse
against these agents upon exposure."
They are saying these results indicate Zack is likely to be immune to getting sick from these diseases, that he will have an adequate "boosted" immune response if exposed to these diseases.
From these experiences, i have come to feel reasonably assured that Zack is protected by the vaccination that he had.
I will share with you an abstract of some research by the Schering Plough research division, they are a vaccine manufacturer, they studied the duration of time that dogs continued to be immune following one puppy shot--the duration was at least 4 years (limited by the length of the study period). The methodology used was disease challenge--that is, the researchers took 10 dogs who had had one vaccination as puppies and kept them under controlled research conditions and then, at much later times, exposed them to the distemper and parvo diseases and hepatitis, and the dogs were still immune. None got parvo or hepatitis after just having one puppy shot. 9 out of 10 did not get distemper, and none died.
Again, this research was sponsored by a vaccine company and done by respected experienced researchers, these facts support, for me, the value of the results. The purpose of the research was to learn more about how long vaccinations remain effective. How long can a vaccine company guarantee the effectiveness of a vaccine, as printed on their label.
Vet Ther. 2004 Fall;5(3):173-86.
Evaluation of the efficacy and duration of immunity of a canine combination vaccine against virulent parvovirus, infectious canine hepatitis virus, and distemper virus experimental challenges.
Abdelmagid OY, Larson L, Payne L, Tubbs A, Wasmoen T, Schultz R.
Schering-Plough Animal Health, Research and Development, 21401 West Center Road, Elkhorn, NE 68022, USA.
The results of this study confirmed that dogs vaccinated subcutaneously with a commercially available multivalent vaccine containing modified-live canine distemper virus, canine adenovirus type 2, canine parvovirus type 2b, and canine parainfluenza virus antigens were protected against sequential experimental challenge 55 to 57 months after initial vaccination given at 7 to 8 weeks of age. All 10 vaccinates were protected against clinical diseases and mortality following parvovirus and infectious canine hepatitis experimental infections. All vaccinates were protected against mortality and 90% against clinical disease following distemper challenge. These data support at least a 4-year duration of immunity for these three "core" fractions in the combination vaccine.
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