View Full Version : 'unifiying theory' on SM, Chiari, spinal bifida, hydrocephalus

12th April 2008, 07:57 PM
This essay on human aspects of these conditions may be of interest:

http://7thspace.com/headlines/279176/a_unifying_hypothesis_of_hydrocephalus_chiari_malf ormation_syringomyelia_anencephaly_and_spina_bifid a.html

A unifying hypothesis of hydrocephalus, Chiari malformation, syringomyelia, anencephaly and spina bifida

This review is a modified version of the Casey Holter Memorial prize essay presented to the Society for Research into Hydrocephalus and Spina Bifida, June 29th 2007, Heidelberg, Germany. It describes the origin and consequences of the Chiari malformation, and proposes that hydrocephalus is caused by inadequate central nervous system (CNS) venous drainage.

A new hypothesis regarding the pathogenesis, anencephaly and spina bifida is described. Any volume increase in the central nervous system can increase venous pressure.

This occurs because veins are compressible and a CNS volume increase may result in reduced venous blood flow. This has the potential to cause progressive increase in cerebrospinal fluid (CSF) volume.

Venous insufficiency may be caused by any disease that reduces space for venous volume. The flow of CSF has a beneficial effect on venous drainage.

In health it moderates central nervous system pressure by moving between the head and spine. Conversely, obstruction to CSF flow causes localised pressure increases, which have an adverse effect on venous drainage.

The Chiari malformation is associated with hindbrain herniation, which may be caused by low spinal pressure relative to cranial pressure. In these instances, there are hindbrain-related symptoms caused by cerebellar and brainstem compression.

When spinal injury occurs as a result of a Chiari malformation, the primary pathology is posterior fossa hypoplasia, resulting in raised spinal pressure. The small posterior fossa prevents the flow of CSF from the spine to the head, as blood enters the central nervous system during movement.

Consequently, intermittent increases in spinal pressure caused by movement, result in injury to the spinal cord. It is proposed that posterior fossa hypoplasia, which has origins in fetal life causes syringomyelia after birth and leads to damage to the spinal cord in spina bifida.

It is proposed that hydrocephalus may occur as a result of posterior fossa hypoplasia, where raised pressure occurs as a result of obstruction to flow of CSF from the head to the spine, and cerebral injury with raised pressure occurs in anencephaly by this mechanism. The current view of dysraphism is that low central nervous system pressure and exposure to amniotic fluid, damage the central nervous system.

The hypothesis proposed in this essay supports the view that spina bifida is a manifestation of progressive hydrocephalus in the fetus. It is proposed that mesodermal growth insufficiency influences both neural tube closure and central nervous system pressure, leading to dysraphism.

Author: Helen Williams
Credits/Source: Cerebrospinal Fluid Research 2008, 5:7

Reposted with permission from 7th Space Interactive: http://7thspace.com/

Karlin Lillington

Cathy Moon
19th April 2008, 06:28 PM
Thanks for posting this article, Karlin!

I printed it and took it to our vet today. Neurology is a special interest of hers, so this article really piqued her curiosity. It will be interesting to watch for further developments.

20th April 2008, 08:05 PM
Apparently there was some criticism of the paper when presented at a conference, but it is one more thing to add to the mix for consideration.