View Full Version : DNA Samples Needed for Episodic Falling Research

21st April 2009, 03:41 AM
Dr. Jacques Penderis (formerly a senior research neurologist at the Animal Health Trust in the UK and now at the University of Glasgow), Dr. Cathryn Mellersh of the Animal Health Trust, and a graduate student, Oliver Forman, are conducting research to try to establish the pattern of inheritance of episodic falling in the Cavalier King Charles Spaniel. They are collecting pedigrees from affected dogs for pedigree analysis, particularly where the disease status of related dogs (e.g. parents and litter mates) are known.

Dr. Penderis reports that funding is now in place to perform a genome scan in the Cavalier to try and identify the genetic region of interest responsible for episodic falling. Funding is still required for the fine sequencing to follow the genome scan. Anyone interested in contributing to these projects should contact Dr. Cathryn Mellersh at the Animal Health Trust, email: Cathryn.Mellersh@ aht.org.uk

For this study Dr. Penderis is very interested in collecting blood samples or cheek swabs for DNA extraction from affected dogs, and normal related dogs. Dr. Penderis requires blood samples from known affected dogs and from as many normal related dogs as possible (particularly litter mates, parents, grandparents and offspring). The study's goal is to develop a genetic test to allow identification of the affected dogs and asymptomatic carriers, so that the disease may be totally eradicated from all tested breeding lines. Dr. Penderis may be contacted at Clinical Neurology / Neurosurgery Service, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, Tel: +(44) 0141 330 5738 (office), Email: j.penderis@vet.gla.ac.uk

For more information on Episodic Falling Syndrome in the CKCS, see http://cavalierhealth.org/episodic_falling.htm