3rd September 2010, 09:09 PM
Any of you have experiences with gentle homeopathy or herbal supplements for SM?
Looking for a supporting supplement that is OK to take with omeprazole :)
7th September 2010, 03:26 PM
I have been looking into this recently too. I have been contacting some people and if you read on Cavalier Health it says that Nerve 8 has been noted to help. I also saw something called "resveratrol" which has been stated to have "anti-inflammatory" properties and there has been publications and things in the news about it. I would think that the anti-inflammatory would help with swelling? I will let you know further information.
That is something that has some studies and I saw in a dog boutique that the owner said is a "miracle" I then went to a health food store with all types of things which you don't know what is what. One said (that was for humans) it helps with prevention and reduction on scar tissue. I am skeptical of that. However, the resveratrol is something that I am digging into. The people who have responded and have looked at it told me that it would be worth a try since it is filled with lots of good things.
7th September 2010, 06:17 PM
Clare Rusbridge says the only complementary approach that has had any effect in dogs she sees is acupuncture. There's been a lot of debate about things like Nerve8 but a couple of human SM discussion boards where people tried it noted it did nothing -- otherwise, as someone tartly noted, wouldn't thousands have rushed to use it and its ingredients been taken on by a large drug company? If something like that could help, then the company should be able to prove its effectiveness and could make millions.
A lot of these companies, when you investigate them, are ordering in who knows what from the far east and selling it on to people who would be normally be cautious even about the kinds of dog chews they buy. If people are interested in holistic medicine and complementary therapies, please only work with a registered and qualified vet with holistic training for any treatments, and never just buy and use things off the internet as there's no regulation and no guarantee of what is in there -- it could be anything. And holistic treatments can have tragic interactions with conventional medications -- or like many human foods, be fine for people and be fatal for animals. Thus it is absolutely critical to only use another treatment in discussion with your prescribing vet. Some pretty scummy people make huge fortunes off the desperate and vulnerable with worthless remedies in this way. I did some research on some of the suppliers of these holistic SM remedies and surprise -- a lot of them are interlinked companies with no real office, just vague PO boxes in cities like Amsterdam serving as a front for their business. One in particular had been chased out of the UK. And they use the same testimonies for all their products on each product's separate website, all from people who only seem to have a first name. :rolleyes: In other words -- they are scam artists. Reading a book called The Spam Kings will reveal how these people operate. Holistic cures and body-part lengthening treatments for men are their stock in trade.
7th September 2010, 06:27 PM
From the well-known Quackwatch website: http://www.quackwatch.com/01QuackeryRelatedTopics/DSH/resveratrol.html
DANGER!!!! This is a grape-derived treatment' -- GRAPES CAN BE FATAL TO DOGS. Hence I would advise completely avoiding giving this to a dog. I'm not sure it would help much anyway, at any rate -- SM isn't directly related to the heart, liver or blood vessels.
Resveratrol: Don't Buy the Hype
Stephen Barrett, M.D.
Resveratrol (trans-3,5,4'-trihydroxystilbene), a compound found largely in the skins of red grapes, is a component of Ko-jo-kon, an oriental medicine used to treat diseases of the blood vessels, heart [1,2], and liver . It came to scientific attention during the mid-1990s as a possible explanation for the "French Paradox"—the low incidence of heart disease among the French people, who eat a relatively high-fat diet . Since then, it has been touted by manufacturers and examined by scientific researchers as an antioxidant , an anti-cancer agent, and a phytoestrogen . It has also been advertised on the Internet as "The French Paradox in a bottle." One company even markets a red-wine extract antioxidant product called "French Parad'ox."
While present in other plants, such as eucalyptus, spruce, and lily, and in other foods such as mulberries and peanuts, resveratrol's most abundant natural sources are Vitis vinifera, labrusca, and muscadine grapes, which are used to make wines. It occurs in the vines, roots, seeds, and stalks, but its highest concentration is in the skin , which contains 50-100 micrograms (µg) per gram . Resveratrol is a phytoalexin, a class of antibiotic compounds produced as a part of a plant's defense system against disease . For example, in response to an invading fungus, resveratrol is synthesized from p-coumaroyl CoA and malonyl CoA . Since fungal infections are more common in cooler climates, grapes grown in cooler climates have a higher concentration .
The resveratrol content of wine is related to the length of time the grape skins are present during the fermentation process. Thus the concentration is significantly higher in red wine than in white wine, because the skins are removed earlier during white-wine production, lessening the amount that is extracted . Grape juice, which is not a fermented beverage, is not a significant source of resveratrol. A fluid ounce of red wine averages 160 µg of resveratrol, compared to peanuts, which average 73 µg per ounce . Since wine is the most notable dietary source, it is the object of much speculation and research.
Resveratrol is also available from supplement pills and liquids, in which it is sometimes combined with vitamins and/or other ingredients. It is also an ingredient in topical skin creams. The supplements are generally labeled as containing from 20 to 500 mg per tablet or capsule. However, the purity of these products is unknown. And, because dietary supplements are loosely regulated, it should not be assumed that the labeled dosage is accurate.
Many studies suggest that consuming alcohol (especially red wine) may reduce the incidence of coronary heart disease (CHD). Several studies have demonstrated that resveratrol has antioxidant properties [7-10]. It is claimed that because it contains highly hydrophilic and lipophilic properties, it may provide more effective protection than other well-known antioxidants, such as vitamins C and E . On the other hand, it is less effective than the antioxidants quercetin and epicatechin found in red wine . Reduced platelet aggregation has also been demonstrated in studies on resveratrol, which could contribute to prevention of atherosclerosis [2,9]. To date, however, most of the research on resveratrol's antioxidant and anti-platelet properties has been done using test-tube or tissue-culture preparations.
Resveratrol is being studied to see how it affects the initiation, promotion, and progression of cancer. With regard to tumor initiation, it has been shown to act as an antioxidant by inhibiting free radical formation and as an anti-mutagen in rat models . Studies related to progression have found that resveratrol induced human promyelocytic leukemia cell differentiation , inhibited enzymes that promote tumor growth [11,12], and exerted antitumor effects in neuroblastomas . Noting that in animal studies, resveratrol was effective against tumors of the skin, breast, gastrointestinal tract, lung, and prostate gland, a recent review concluded:
During the last decade, resveratrol has been shown to possess a fascinating spectrum of pharmacologic properties. Multiple biochemical and molecular actions seem to contribute to resveratrol effects against precancerous or cancer cells. Resveratrol affects all three discrete stages of carcinogenesis (initiation, promotion, and progression) by modulating signal transduction pathways that control cell division and growth, apoptosis, inflammation, angiogenesis, and metastasis. The anticancer property of resveratrol has been supported by its ability to inhibit proliferation of a wide variety of human tumor cells in vitro. These . . . data have led to numerous preclinical animal studies to evaluate the potential of this drug for cancer chemoprevention and chemotherapy .
Recent studies in laboratory mice have found increased survival and lower incidence of several diseases and conditions associated with aging, but the results are contradictory. Protective effects have been found in mice fed a high-fat or a low-calorie diet, but one study found that mice fed a standard diet beginning at age 12 months did not live longer [15-17]. One of the studies was reported in a New York Times article which described how a researcher was taking resveratrol himself and had founded Sirtris Pharmaceuticals to develop chemicals that mimic the role of resveratrol but at much lower doses . GlaxoSmithKline acquired Sirtris for $720 million in 2007 and hopes to develop "drugs that target the sirtiuns, a recently discovered family of seven enzymes associated with the aging process." 
After reviewing the animal studies, the highly respected Medical Letter concluded: "Resveratrol appears to produce some of the same effects as calorie-restricted diets that have reduced the incidence of age-related diseases in animals. Whether it has any benefit in humans remains to be established." 
Caution Is Advisable
Although laboratory tests have demonstrated that resveratrol might help prevent cardiovascular disease and cancer, there are several reasons why a population-wide increase would be premature.
The research on resveratrol has focused on its short-term effects and has been dominated by in vitro (laboratory) studies on non-human models.
Not enough is known about the absorption and clearance of resveratrol, the identities of its metabolic products, or its effects on the liver.
Resveratrol's role as a potentiator of breast carcinomas may significantly limit its use.
Its main dietary source is red wine. Not only is its concentration in wine extremely variable, but recommending increased consumption of red wine to boost resveratrol intake could certainly do more harm than good. In spite of any beneficial aspects, red wine and other alcoholic beverages pose health risks that include liver damage and physical addiction. While taking resveratrol pills is certainly safer than heavy wine consumption, supplementing with unproven substances is generally unwise. At this point, occasional use of red wine seems far more prudent.
The Bottom Line
Epidemiologic studies can find associations between the consumption of foods or dietary supplements and various health outcomes. Animal experiments can demonstrate what can happen in the species tested. However, only human clinical trials can determine whether supplementation is useful for humans. Resveratrol has not been tested in clinical trials, and most clinical trials of other antioxidants have failed to demonstrate the benefits suggested by preliminary studies. Some substances—most notably beta-carotene—have even produced adverse effects. My advice is to ignore the hype surrounding resveratrol and eat a balanced diet that contains adequate amounts of fruits and vegetables.
Celotti E and others. Resveratrol content of some wines obtained from dried Valpolicella grapes: Recioto and Amarone. Journal of Chromatography A 730(1-2): 47-52, 1996.
Soleas GJ, Diamandis EP, Goldberg DM. Resveratrol: A molecule whose time has come? And gone? Clinical Biochemistry 30:91-113, 1997.
Kopp P. Resveratrol, a phytoestrogen found in red wine. A possible explanation for the conundrum of the 'French paradox'? European Journal of Endocrinology 138:619-620, 1998.
Jang M and others. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 275:218-220, 1997.
Gehm H and others. Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor. Proceedings of the National Academy of Sciences U.S.A. 94:557-562, 1997.
Sanders TH, McMichael RW. Occurrence of resveratrol in edible peanuts. Presentation, American Oil Chemists Society, Las Vegas, Nevada, 1998. Discussed in Peanuts contain significant amount of plant compound that may prevent risk of heart disease and cancer, a news release from The Peanut Institute, Sept 8, 1998.
Chanvitayapongs S, Draczynska-Lusiak B, Sun AY. Amelioration of oxidative stress by antioxidants and resveratrol in PC12 cells. Neuroreport 8:1499-1502, 1997.
Belguendouz L, Fremont L, Gozzelino MT. Interaction of transresveratrol with plasma lipoproteins. Biochemical Pharmacology 55:811-816, 1998.
Rotondo S and others. Effect of trans-resveratrol, a natural polyphenolic compound, on human polymorphonuclear leukocyte function. British Journal of Pharmacology 123:1691-1699, 1998.
Frankel EN, Waterhouse AL, Kinsella JE. Inhibition of human LDL oxidation by resveratrol. Lancet 341:1103-1104, 1993.
Clement MV and others. Chemopreventive agent resveratrol, a natural product derived from grapes, triggers CD95 signaling-dependent apoptosis in human tumor cells. Blood 92:996-1002, 1998.
Fontecave M and others. Resveratrol, a remarkable inhibitor of ribonucleotide reductase. FEBS Letters 421:277-279, 1998.
Chen Y and others. Resveratrol-induced cellular apoptosis and cell cycle arrest in neuroblastoma cells and antitumor effects on neuroblastoma in mice. Surgery 136:57-66, 2004.
Bishayee A. Cancer prevention and treatment with resveratrol: from rodent studies to clinical trials. Cancer Prevention Research 2:409-418, 2009.
Baur JA and others. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444:337-342, 2006.
Pearson KJ and others. Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metabolism 8:157-168, 2008.
Barger JL and others. A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice. PLoS One 3:e2264, 2008.
Wade N. Substance in red wine extends life of mice. New York Times, Nov 1, 2006.
About us. Sirtris Pharmaceuticals Web site, accessed Sept 20, 2009.
Resveratrol. The Medical Letter on Drugs and Therapeutics, 51:74-75, 2009.
10th September 2010, 11:41 PM
I'd like to clarify for anyone considering homeopathic remedies what exactly this branch of medicine entails:
The name is derived from the base idea that " like will cure like", so if your symptoms are vomiting, fever, etc. a poison like arsenic may be used. Solutions are diluted until the poison is no longer dangerous, with the belief being that more dilute solutions are stronger. Homeopathic remedies available today are diluted 12x or 30x typically, at which point it is statistically unlikely that even a single molecule of the original ingredient remains, all you're purchasing is water.
For anyone interested in alternative medicine please do not waste your time, money, or hopes on homeopathy. Accupuncture is the best of alternative medicine in my opinion (it works on horses, and horses don't have a placebo effect), but there are other methods too, just beware because anyone can claim to have the miracle cure.
11th September 2010, 10:38 AM
Please do not dismiss homoeopathy like that - there is plenty of evidence to show its effectiveness - I have personal experience of homoeopathy for people and animals - it cannot possibly be placebo effect on animals...
Just because we do not understand how something works, we should not dismiss it - there are still many drugs in conventional medicine that we do not understand their mechanism.
I do not wish to give people false hope, and you do indeed have to be very careful where you obtain homoeopathic remedies, ideally from a qualified homoeopathic vet or reputable supplier - in the UK, www.gentletouchremedies.co.uk; Ainsworths, Helios.
Obviously there are conditions for which it is maybe not suitable - or may be used in conjunction with other treatments.
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