Thank you Rod for the link you sent through, very informative, also Mel and Karen thank you for your reassuring and helpful advice, feeling a lot happier, the reason why Ruby was so distant and vague, when she came home from vets is because they had sedated her with Buprenorphine, she was away with the fairies lol, next day she was fine. I am feeling quite positive at the moment, and she is responding ok so far with her meds, everything you have expressed in your posts is basically right, some days better than others. She had a visit to see the vet today, just to see how she was doing with the meds, then back in three weeks, i have had there coats clipped short, to keep them cool,its strange how you become so focused on there health, especially Ruby its been a constant battle over the years, find myself scrutinising every little ailment,but she is such a stoic little dog, i will keep you all updated with things, thank you all so much. Karen, Ruby and Sadie xxx