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Thread: Gabapentin - high liver enzymes?

  1. #1
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    Default Gabapentin - high liver enzymes?

    My Ruby, TedBear, has been on Gabapentin for 14 months. He's just had a
    blood panel run as per Clare Rusbridge's recommendation, checking for
    liver function.

    The results have just come back and are worrying - very high for liver
    enzymes. He is going back on Monday for a full elimination test, where
    he will be fasted overnight, blood taken, given a meal and then further
    blood taken 2 hours later. Hopefully this will give us a better idea of
    what is happening.

    Obviously he has to stay on Gabapentin - he is on a combination of
    treatments including supplements and homoeopathy, but if any of these
    are stopped then there is a very noticeable deterioration. Normally he
    is actually very well, despite having a poor scan and multiple syrinxes.


    Has anyone else had this result with Gabapentin please?


    ***have posted this in both general health and SM/MVD forum***
    Nicki and the Cavalier Clan Our photos www.scotlandimagery.com
    Supporting www.rupertsfund.com and www.cavaliermatters.org

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    Hi Nicki,
    Sorry to hear this. Abbey goes in this fall for her blood panel. I'll have to mention this to our vet. Please keep us posted on what you learn next week.
    Jen, Abbey (Tri Cavalier) & Gus (White Min. Schnauzer)

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    Thanks Jen - sorry didn't mean to worry you as well

    I think though that I will be reminding everyone with a dog on Gabapentin to do annual checks...


    I hope that Abbey is ok and that her results will be good - I'm sure this is prob uncommon - I haven't heard of it before.
    Nicki and the Cavalier Clan Our photos www.scotlandimagery.com
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    Oh no worries! I'm glad you've brought it up, it's good for people to be reminded!!
    Jen, Abbey (Tri Cavalier) & Gus (White Min. Schnauzer)

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    I hope, TedBear's second round of tests next week are more encouraging. And thank you for the reminder. Since Spencer's on such a high dose (total of 400mg a day) I'm thinking of asking our vet to do this test in August.

    I have to get a liver panel every 3 months due to some medication I'm on. Is the pup version just like the human- fasting for 12 hours before the blood test?
    Spencer and his mom, Whitney

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    Sorry to hear that you have to have liver panel tests Whitney

    The first test was just a general blood panel, which checks for liver function too. The test on Monday is an elimination test, where they are fasted from the night before, blood is taken, the dog is given a meal and then further blood is taken two hours later.

    TedBear isn't a good eater at the best of times - I tried to give him a meal at the vets yesterday but he wouldn't eat it {not even fresh chicken, his favourite} so I'm not sure what to take for him to eat really.


    Dr Abramson {formerly from O S U now in Houston} is recommending 300mg 3x daily {Gabapentin} - which is a really high dose! Some dogs don't seem to tolerate that higher dose, one of mine was really sleepy just on 100mg 2x daily.

    TedBear was on 100mg 3x daily from April 2006 until Oct 2006 - since then, he's been on 100mg 2x daily.

    Is Spencer still on 300mg Cimetidine?
    Nicki and the Cavalier Clan Our photos www.scotlandimagery.com
    Supporting www.rupertsfund.com and www.cavaliermatters.org

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    Yes, still 300mg of that in combo with the gabapentin. Things seem okay though I am noticing more trembling in his front legs and a bit of weakness overall. Our next appointment with the neurologist isn't until November but I'm going to just keep watching him like a hawk for the rest of the summer and possibly move the appointment up if I still see the same symptoms.
    Spencer and his mom, Whitney

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    I hope Tedbear's results prove to be OK.

    I have been on Gabapentin myself for over 7 years for nerve pain/allodynia and interestingly have never heard of any connection with it affecting the liver. I've never been offered any tests at all. It affects me brainwise, clouds my thinking, but the NHS being what it is I have not had any follow up since I have been on it. Is there a definite link with the liver being affected? I think sometimes we humans would do better with a vet than with some doctors I have known. I used to joke that if a vet had done my hysterectomy many moons ago I would have been up and running about in days not weeks!

    All that aside, my best wishes for Tedbear. xx. It must be very worrying.

    Added on later: Have just looked it up and found that the gabapentin is metabolised by the liver in dogs - unlike in humans where it is not - so my comparison has no real relevance. Sorry to confuse the issue.
    Last edited by Lucy's mum; 6th July 2007 at 10:55 PM.
    Annie and Lucy (tri girl born Feb 06) and Henry (Blenheim boy born June 06)

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    Thanks Annie for that info on why the liver would be involved. I never even knew a blood panel was recommended --need to to clarify that on the SM site and aso get Leo in as he's been on gabapentin about a year now I think. Sure hope TedBear improves -- it is really hard to see them going through any extra difficulty.
    Karlin
    Cavaliers: Jaspar Leo Lily Tansy Libby (foster) Mindy (foster)
    In memory: Lucy
    Cavalier SM Infosite:www.smcavaliers.com

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    Red face

    I hope it all goes well Nicky - fingers crossed for you.

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