Question about Gabapentin

[Cathy Moon]

Thanks to each of you for the dosage info.

Just one more question - Clare's document shows NSAIDs as being the first choice for pain med, followed by Gabapentin if it doesn't work. Is that what was tried on your cavs at first? Just wondering, because I thought NSAIDs would be a little hard on their digestive systems over the long term.

[Karlin]

I suppose they all have their side effects. People use them extensively though all the time so I guess it is weighing up each choice in the balance and monitoring for side effects. Different NSAIDS are tolerated in different ways I think. I cannot take ibuprofen myself as I had severe problems with it eventually after long term occasional use. But I could use others if needed.

My vets followed the protocol as they needed to under Irish law to prescribe a human medication not licensed for use in animals. They needed their records to reflect that we'd followed a standard pathway.

[Ruth M]

Hi - just been reading this thread (sooo helpful - thx). Does anyone know if its OK to open the gabapentin capsules and feed the drug in powder form mixed with food/treat?

Also - apart from the tiredness (does this get better??) are any of your dogs showing any gabapentin side affects? My vet has assured me there are no long term side effects, however Tilly is only 18 months old and on 300 mg daily - which we may have to increase. Just wondered if any one has been using this drug long term ..

Thanks - Ruth

[Karlin]

I used to take it out and mix it because I used half a capsule but it it better to give it in the capsule I think -- I just put it in a bit of soft cheese (eg Laughing Cow) and have no problems with pills.

There can be some side effects -- sleepiness especially on high doses, dizziness etc is reported in people. But generally it is well tolerated.

300mg daily wouldn't be particularly high according to Clare Rusbridge's protocol. Just keep in mind the condition is progressive and gabapentin doesn't help the condition at all -- it only helps with the pain and therefore the symptoms. If you have a cavalier with very pronounced symptoms at only 18 months, you'd certainly want to seriously discuss the surgery as an option with a neurologist familiar with SM, if that is something you would consider. It isn't an option for all cavaliers, nor a choice everyone wishes to make for all sorts of valid reasons, but it is the only way of possibly stopping the progression.

[Nicki]

I would definitely advise keeping the powder within the capsule - it can actually be very corrosive to the bowel lining.

Teddy has been on 900mg per day for some months now, without any side effects - the sleepiness wears off in most dogs, and generally it is well tolerated as the body processes the drug very quickly, hence the need to give 8 hourly doses.

He has been taking the drug for over 2 years now, and I'm aware of other dogs who've been on it longer. Clare Rusbridge's drug protocol suggests annual liver function tests whilst taking this, but when I was last in contact with her, she wasn't aware of any dogs having liver problems.

Wishing you well with Tilly.

[Karlin]

Forgot to mention that Leo too has been taking it for over two years with no problems or obvious side affects.

[maneumann]

Jack takes 75mg every 8 hours. They are custom compounded (so no pill cutting necessary) for about $75 for a month supply w/shipping included.