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Thread: SM pain management study

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  1. #1
    Join Date
    Dec 2007
    Southwest Florida
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    Default SM pain management study


    I'm sure Karlin has posted this info before, but I just saw it on another site so I'll post the info again.

    New therapeutic agent to provide improved pain relief. The Clinical Investigation Center at the University of Minnesota College of Veterinary Medicine is conducting a 14-day study of CM/SM in Cavalier King Charles spaniels. The project will examine treatment with a new therapeutic agent which is hoped to provide improved relief from the pain associated with this condition. Before a CKCS can be enrolled in the study, it will need to have been diagnosed by MRI scan with CM/SM within the last 8 months. This evaluation can be performed at the University of Minnesota Veterinary Medical Center. Additionally, prior to enrollment, the dog must have some clinical signs of scratching, pain, and sensitivity to touch. Cavaliers aged from 1 year to 11 years and weigh between 8.8 lbs. and 28.6 lbs. to eligible. Dogs currently on other pain medications are still eligible but we will have a transition period to wean them off current therapies. Dogs intended for breeding or with concurrent medical conditions including ear disease, grade 3 to 5/6 MVD heart murmur, or epilepsy are not eligible for the study. The initial neurological evaluation is offered free of charge, and and if eligible for study enrollment, the MRI is also free of charge.

    Dogs enrolled onto this study will be randomly allocated the new therapy or placebo, in a 1 to 1 ratio. A placebo is a product which looks like the investigational product, but contains no active ingredient. You and the veterinarian will not know which treatment your dog is receiving; this is known as a “masked” study. This helps the accuracy of the drug evaluation. The dog will still receive basic pain medication with carprofen (Rimadyl®) regardless of whether they are taking the new drug or the placebo.

    Once the diagnosis of syringomyelia has been confirmed by MRI, a blood sample will be taken to determine if the dog is in good general health. Participating Cavaliers will be prescribed carprofen (Rimadyl®) and will need to take this treatment twice daily for a minimum of 7 days prior to enrollment on the study. The dog will then need to return to the Veterinary Medical Center to be enrolled in the study and will be assigned either the new therapy or placebo. The dog will take this medication twice daily in addition to the carprofen for 14 days. There would be two further follow-up visits- one after 7 days of treatment and one after 14 days of treatment (end of study visit).

    The principal investigator is Dr. Ned Patterson. For more information, contact Marianne Robeck, study technician, telephone 612-624-1352, email website (May 200
    Last edited by chloe92us; 1st June 2008 at 02:56 AM. Reason: added location in heading
    Trisha in Southwest Florida
    Cavaliers: Casey, Ollie, & Winston and usually a foster or two! Cats: Pebbles & Benson


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