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Thread: Different Research ?

  1. #1
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    Default Different Research ?

    Just noticed on the UK CKCS CLUB Web Site that the Club has given £5.000,for the Embryology Research.

    Is this a different type of research from that which was carried out by Marin-Padilla in 1981 and also by Nishikawa and others in 1997,about the Pathogenesis of CM as Mesoderm and Insufficiency during Embrology ,-causing insufficent scope for the Mesoderm and ectoderm layers to develope. Or alternatively premature growth Plate Closure.?
    Bet (Hargreaves)

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    I am sure this is the recent research on stillborn puppies that showed a misalignment in growth and development between the skull and the brain. I believe this project is to continue to be funded. Sheena is a contact point on this research.
    Karlin
    Cavaliers: Tansy : Mindy Connie Roxy Neasa Gus
    In memory: My beautiful Jaspar Lucy Leo Lily Libby

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    Default Different Research?

    So will this Research be able to know if the Cavaliers have Large Brains ?

    Is it the Large Brains of the Cavaliers that 's giving them SM.?

    Do the Other Breeds of Dogs with SM not have Large Brains ?

    Then if it's only Cavaliers with Large Brains who are Suffering from SM ,are those Cavalier Large Brains being caused by certain Gene/Genes applicable only to our Cavalier Breed.
    Bet (Hargreaves)

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    This research should help to give more insight but I don't know if it will be able to answer all those questions. The initial research indicated that the skull growth ceased before brain growth had finished and that brains were larger than would be expected for skull size in the breed. There's a summary of the research posted on the UK club website I think now.
    Karlin
    Cavaliers: Tansy : Mindy Connie Roxy Neasa Gus
    In memory: My beautiful Jaspar Lucy Leo Lily Libby

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    Default Different Research?

    Thanks Karlin.,

    I don't know but would it be down to finding the Faulty Gene/Genes having an influence on what is happening.

    As has been mentioned if the Brain was growing too much ,the Bone should keep up with it .

    In the Cavaliers this relationship is lost, so if this is happening has it to thought that Gene/Genes are involved.

    I can't work out why other Breeds have SM ,but is it the same reason that has been given for our Cavalier Breed, that their Brain is growing too much, the Bone should keep up with it.

    If that's the case and Gene/Genes are involved ,have the Other Breeds got the same Gene/Genes as Cavaliers. Or do the other Breeds have a different type of SM ?
    Bet (Hargreaves)

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    Quote Originally Posted by Bet View Post
    I don't know but would it be down to finding the Faulty Gene/Genes having an influence on what is happening.
    Geneticist Professor Dr Guy Rouleau mentioned in his video presentation at the conference last year something about “waiting till the cows come home”. I think that all things have to be considered yes even Environmental Factors, BUT due to LIMITED FUNDS AND TIME I think that research should maintain most focus on the highly probable rather than the lowly probable and this decided by researchers with specialist expertise.

    Example - Highly Probable is Fibrillin 1.
    Genetic studies in humans with Chiari Malformation Type 1 have indicated significant areas (high LOD scores) on chromosomes 9 and 15. On chromosome 15 there is a very large gene called Fibrillin 1 which has already been associated with genetic conditions that involve mis-shapen skulls including Marfan syndrome and Shprintzen-Goldberg syndrome (the defects in this syndrome include CM). Fibrillin has been suggested as a possible positional candidate gene. It is a very large gene coding for an amino acid which is a constitutive element of extracellular microfibrils in connective tissues. Fibrillin 1 sequence analysis in affected CKCS, Yorkshire Terrier, Bull Terrier, Boston Terrier, Chihuahua, Brussels Griffon and King Charles breeds is ongoing.
    .

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    Default Different Research?

    Sorry Folks about going on more about this.!!!

    EddyAnne mentioned about the Gene FIBRILLIN 1,and Fibrillin 1 sequence analysis in CKCS, Yorkies, Bull Terriers ,Boston Terrier ,Chihuahua ,Brissels Griffon ,King Charles Spaniel Breeds,

    Would all those other Breeds also have Large Brains?

    EddyAnne also mentioned that this Research is ongoing ,is this the Genome Research in Canada.

    Does it follow on then, if those other Breeds don't have Large Brains like Cavaliers, do the Cavaliers have a different type of Gene causing their Brain to be Large.
    Bet (Hargreaves)

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    Bet, maybe you should have a look again at Dr Guy Rouleau's video presentation at the conference where he certainly does mention Fibrillin 1.
    Dr Clare Rusbridge today even mentions on her website "Fibrillin 1 sequence analysis in affected CKCS, Yorkshire Terrier, Bull Terrier, Boston Terrier, Chihuahua, Brussels Griffon and King Charles breeds is ongoing." Bet where do you think it is ongoing?
    http://www.veterinary-neurologist.co.uk/research.htm

    I thought that you mentioned that you read Clare's website which included this.
    http://www.veterinary-neurologist.co.uk/part1.htm#4

    The Ann Conroy Trust is for HUMANS and the Trust feels that what Clare is doing regarding dogs is great where they even presented her with a cheque. Well I think that is rather interesting and even in light of what I posted about Fibrillin 1.
    http://www.veterinary-neurologist.co.uk/act_trust.htm
    .

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    Default Different Research?

    Thanks EddyAnne, it had'nt registered about Fibrillin 1 ,so this research is now taking place in Canada. That's good to know.
    Bet (Hargreaves)

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    Bet I remember in Dr Guy Rouleau's video presentation which was last year at the very end he mentioned funds, maybe we should have a look at that part again and think about what I posted earlier.
    "due to LIMITED FUNDS AND TIME I think that research should maintain most focus on the highly probable rather than the lowly probable and this decided by researchers with specialist expertise."
    .

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