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Thread: Dr. Mark Oyama's October 2009 Video on MVD

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    Default Dr. Mark Oyama's October 2009 Video on MVD

    An October 2009 video by cardiologist Mark Oyama on MVD in Cavaliers (and an overview of canine heart disorders in general) may be watched at http://ondemand.thecanonhouse.com/CHF/Oyama/oyama.html

    This was his presentation to the AKC National Parent Club Canine Health Conference last October. Be patient while watching; he starts out talking about cardiomyopathy in Boxers, but soon enough he turns to MVD in Cavaliers.
    --
    Rod Russell
    Orlando, Florida

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    I have just caught up with myself a little, so managed to find the time to watch this. Very interesting indeed.
    Also the later discussion on survival time versus quality of life.

    Thank you Rod for posting this link, and the other one on Simon Platt's talk, which I will watch tomorrow.
    Margaret C

    Cavaliers......Faith, The Ginger Tank and Woody.
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    Rod thanks for posting the address. I found it very interesting even though I had read the latest publishings on MVD. Interestingly Mark Oyama mentioned Fibrillin-1 just before he went into mentioning Serotonin, and from a genetical point of view I would be interested in what Genetic Research may reveals regarding MVD and also CM, and note the following part from Clare Rusbridge's webpage at this address.
    http://www.veterinary-neurologist.co.uk/research.htm

    Finding the gene(s) for Chiari malformation
    Investigation of possible candidate gene - Fibrillin 1
    Genetic studies in humans with Chiari malformation type 1 have indicated significant areas (high LOD scores) on chromosomes 9 and 15 (for more information click here). On chromosome 15 there is a very large gene called Fibrillin-1 which has already been associated with genetic conditions that involve mis-shapen skulls including Marfan syndrome and Shprintzen-Goldberg syndrome (the defects in this syndrome include CM). Fibrillin has been suggested as a possible positional candidate gene. It is very large gene coding for an amino acid which is a constitutive element of extracellular microfibrils in connective tissues. Fibrillin 1 sequence analysis in affected CKCS, Yorkshire Terrier, Bull Terrier, Boston Terrier, Chihuahua, Brussels Griffon and King Charles breeds is ongoing.
    .

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    Thank you Rod for posting this. I found the the Serotonin theory really interesting!
    Tania and The Three Cavaliers!
    Dotty!- A Sweet Little Tri
    Molly - Pretty Tri Dougall - Gorgeous Blenheim

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    Yes really interesting and Oyama mentioned something about clinical trials on dogs to study the impact of a drug that inhibits the Serotonin.

    Meanwhile Genetic Researchers are looking into DNA and I noted Oyama mentioned Fibrillin-1 regarding MVD, and note Clare Rusbridge also mentions Fibrillin-1 regarding CM, and both MVD and CM involve Cavaliers.

    Regarding Serotonin the following Abstract is from this address.
    http://www.ingentaconnect.com/conten...86oo.alexandra

    Serum Serotonin Concentrations in Dogs with Degenerative Mitral Valve Disease
    Authors: Arndt, J.W.1; Reynolds, C.A.1; Singletary, G.E.1; Connolly, J.M.2; Levy, R.J.2; Oyama, M.A.1

    Source: Journal of Veterinary Internal Medicine, Volume 23, Number 6,
    November/December 2009 , pp. 1208-1213(6)
    Publisher: Blackwell Publishing

    Abstract:

    Background:
    Increased serotonin (5HT) signaling has been implicated in valvular disease of humans and animals, including canine degenerative mitral valve disease (DMVD). High circulating 5HT concentration is a potential source of increased signaling, and serum 5HT concentrations have not been previously reported in dogs with DMVD.

    Hypothesis:
    Dogs with DMVD and small breed dogs predisposed to DMVD have higher serum 5HT concentrations than large breed controls.

    Animals:
    Fifty dogs affected with DMVD, 34 dogs predisposed to DMVD but without cardiac murmur or echocardiographic evidence of DMVD, and 36 healthy large breed control dogs.

    Methods:
    Prospective analysis. Serum 5HT concentration was measured by an ELISA test.

    Results:
    Median serum 5HT concentration was significantly higher in dogs with DMVD and in dogs predisposed to DMVD as compared with controls (DMVD, 765.5 ng/mL [interquartile range, 561.3-944.4]; predisposed, 774.9 ng/mL [528.3-1,026]; control, 509.8 ng/mL [320.8-708.8]; P= .0001). Subgroup analysis of predisposed dogs indicated significantly higher serum 5HT concentrations in Cavalier King Charles Spaniel (CKCS) dogs than in other breeds (CKCS, 855.0 ng/mL [635.8-1,088]; non-CKCS, 554.2 ng/mL [380.6-648.4]; P= .0023). Age, platelet count, and platelet morphology were not correlated with 5HT concentration in any group.

    Conclusions and Clinical Importance:
    Dogs with DMVD had significantly higher serum 5HT concentrations when compared with large breed control dogs. Healthy CKCS dogs had significantly higher serum 5HT concentrations than other healthy dogs predisposed to DMVD. Additional investigation into a possible role of 5HT in the pathogenesis of DMVD is warranted.
    .

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    Interesting that serotonin is used as an anti-depressant in human medicine
    Margaret C

    Cavaliers......Faith, The Ginger Tank and Woody.
    Japanese Chins.... Dandy, Benny, Bridgette and Hana.
    Remembered with love......... Tommy Tuppence and Fonzi

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    Quote Originally Posted by Margaret C View Post
    Interesting that serotonin is used as an anti-depressant in human medicine
    Margaret yes and from me some simple layman thoughts about Serotonin.

    Serotonin medications have been around for many years, and humans and dogs manufacture their own Serotonin where there are "normal levels". High levels of Serotonin over a period of time at the heart valves could cause medical induced or driven MVD, and where this might occur then doctors and vets may want to periodically listen to the heart with their Stethoscope. But I think that in most cases Serotonin medication is given where for one reason or another the levels of Serotonin have dropped below "normal levels" and they want to restore it back to "normal levels".

    In relation to medications to reduce high levels of Serotonin at the heart valves. Well that might require a special medication that targets and does NOT reduce the levels of Serotonin elsewhere within the body as a reduction elsewhere may lead to various problems.

    With Cavaliers the question is what is causing the high levels of Serotonin at the heart valves. Well we do know a lot of Cavaliers have Heritable MVD and why Researchers are looking into DNA for the cause. Maybe think of high levels of Serotonin at the heart valves as "secondary" where the actual cause comes from the genes, avoid breeding those genes that do this then there may be NO need for special Serotonin medications.
    .

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    Over the years I have met a few people who have taken Serotonin to lift their spirits! Dr. Oyama mentioned out of all the dogs The Cavaliers are the Happiest Dogs in the World! probably because of the high levels of Serotonin. In laymans language, does this mean when MVD was not around, would the temperament of the Cavalier been different? Are the high levels of Serotonin relatively new. I will have a transcript of this around Wednesday if anyone would like a copy.
    Tania and The Three Cavaliers!
    Dotty!- A Sweet Little Tri
    Molly - Pretty Tri Dougall - Gorgeous Blenheim

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    Tania, I would really appreciate a copy of your transcript - my speakers are on the blink and my lip-reading skills aren't great! I'll PM you my own email address if that's OK.

    Kate, Oliver and Aled

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    Thanks for posting Rod, very interesting presentation and results, just wondering if you or anyone else knows what is the serotonin-blocking agent (drug K, used in western blot analysis expts), Mark Oyama is investigating? Ok, just reviewed a publication, think maybe its 5HT-R2A ketanserin?
    Last edited by amanda L; 24th March 2010 at 04:48 PM.
    Amanda
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    "We never really own a dog as much as he owns us" -Gene Hill-

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