Replacement creams and lotions are quite common now but there is threat to others, including pets. Two Cavaliers are noted to have been affected.
First two paragraphs. The article is long but good.

The spreading popularity of topical hormone treatments in people — especially but not exclusively menopausal women — is having unintended medical consequences for the users’ pets.

Spayed dogs and young female puppies are showing up in veterinary exam rooms with markedly swollen vulvas as if they are in heat. Male dogs present with enlarged mammary glands and abnormally small penises. Animals of both genders experience fur loss.