Do you remember a while back Mark Oyama had a conference about this and he linked MVD to Serotonin. I have the hard copy of this conference if anyone would like it:- This is a little snippet.
. And interestingly in the Cavaliers as compared to all other non-Cavalier breeds, they have a higher circulating blood serotonin levels.
One question that a lot of people always ask me is, well, what are the other effects of really high circulating serotonin levels. So we like to joke we have to ask a neurologist, but I like to joke itís very rare that you meet a Cavalier who is not extremely happy. They are like the happiest dogs in the entire world I think. And so itís interesting to me that within this preliminary phase they have lots of serotonin running around. I mean remember, high serotonin at least in the central nervous system you feel good, thatís anti-depressants. So maybe all these Cavaliers are Ė maybe they are really depressed about their mitral valve disease but they are not showing it because they have a lot of serotonin. So that would make a good study.
So we know that serotonin activates those mitral valve cells, so mitral valve cells just kind of sitting back, they shouldnít be doing a whole lot. If you put serotonin in with those mitral valve cells, they start to become more active and start to make a lot of that glycosaminoglycan or GAG. Okay, so I debated whether or not put a bunch of these slides in here but I think itís instructive to look at.
So the question then is, is serotonin somehow linked to the development or progression of valve disease. The fact that there is serotonin generating pathways within the valves and maybe a higher circulating serotonin in predisposed dogs particularly the Cavalier, does that have something to do with the high incidence of mitral valve disease particularly in the Cavalier, then also the progression of disease once that valve starts to weaken and fail.
Tania and The Three Cavaliers!
Dotty!- A Sweet Little Tri
Molly - Pretty Tri Dougall - Gorgeous Blenheim