Kate H
Well-known member
The Cavalier Health Day at the Royal Veterinary College yesterday was very interesting. Well-attended - about 80 people there, I would guess. Margaret and Tania took a lot of notes and will no doubt be sharing them with you when they have recovered - we all worked hard to take in a lot of information!
The piece of information that struck me most came in the last talk of the day, from Imelda McGonnell who heads the Foetal Tissue Project at the RVC. They are examining stillborn Cavalier puppies to see how their skulls develop in the womb, and have found that all the 20 puppies they have examined have similar deficiencies in the quality of their bone at the back of the skull, which both protects and supports the brain. They think this is because the molecule that organises the development of the foetus in the womb is not giving the correct instructions to the proteins that do the actual work. One protein in particular, which is responsible for bone production (as well as muscle development and other things), is not behaving normally and also seems unable to communicate with the brain to tell it when to stop growing. What I found fascinating was that this protein also has a role in the development of the heart, and Dr McGonnell made the very cautious and tentative suggestion that the same lack of molecule instruction and resulting protein failure could be responsible for both Chiari Malformation in the skull (and so SM) and the changes in the heart which lead to MVD - in other words, we could be dealing with one source for the two major health problems in Cavaliers, not two totally separate sources. Which is pretty mind-boggling... (If I've got anything wrong here, I'm sure Margaret or Tania will correct me! My brain was having to work hard at the end of a long day.)
Kate
The piece of information that struck me most came in the last talk of the day, from Imelda McGonnell who heads the Foetal Tissue Project at the RVC. They are examining stillborn Cavalier puppies to see how their skulls develop in the womb, and have found that all the 20 puppies they have examined have similar deficiencies in the quality of their bone at the back of the skull, which both protects and supports the brain. They think this is because the molecule that organises the development of the foetus in the womb is not giving the correct instructions to the proteins that do the actual work. One protein in particular, which is responsible for bone production (as well as muscle development and other things), is not behaving normally and also seems unable to communicate with the brain to tell it when to stop growing. What I found fascinating was that this protein also has a role in the development of the heart, and Dr McGonnell made the very cautious and tentative suggestion that the same lack of molecule instruction and resulting protein failure could be responsible for both Chiari Malformation in the skull (and so SM) and the changes in the heart which lead to MVD - in other words, we could be dealing with one source for the two major health problems in Cavaliers, not two totally separate sources. Which is pretty mind-boggling... (If I've got anything wrong here, I'm sure Margaret or Tania will correct me! My brain was having to work hard at the end of a long day.)
Kate