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Thread: Study of SM in 555 asymptomatic CKCS: 70% affected by age 6

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    Default Study of SM in 555 asymptomatic CKCS: 70% affected by age 6

    Newly published paper from a research team including Penny Knowler and Dr Clare Rusbridge.

    Truly shocking figures -- in cavaliers with no symptoms, scans found SM already present in a FOURTH of all dogs by age 1 and 70% in dogs over 6.

    This means overall incidence in the breed is far higher than 70%, as this doesn't even include symptomatic dogs.

    How can any remaining doubting breeder now argue that this is not a widespread and serious problem and the chance that the still-heard claim that it 'isn't in my lines' might even remotely be true is virtually nil if such a high rate of dogs with NO symptoms scan with SM. The only good news is that if such a large percentage had no symptoms still at age 6 -- then clearly there are dogs less inclined to develop serious pain with this condition -- again, this is exactly why breeders need to scan their older dogs, not just the dogs coming to breeding age.

    There is plenty of cash in Rupert's Fund right now for breeders to use towards such scans.

    Abstract:

    Prevalence of asymptomatic syringomyelia in Cavalier King Charles spaniels
    J. E. Parker, S. P. Knowler, C. Rusbridge, E. Noorman, N. D. Jeffery

    The prevalence of syringomyelia was investigated in a sample population of 555 Cavalier King Charles spaniels. All dogs, which were declared by their owners to be showing no clinical signs of syringomyelia, underwent MRI to determine the presence or absence of the condition. Data were analysed by logistic regression to determine the effects of sex and age on the prevalence of syringomyelia. Only increased age was found to have a significant effect. The prevalence of syringomyelia was 25 per cent in dogs aged 12 months, increasing to a peak of 70 per cent in dogs aged 72 months or more.
    Published in the Veterinary Record.
    Karlin
    Cavaliers: Jaspar Leo Lily Tansy Libby (foster) Mindy (foster)
    In memory: Lucy
    Cavalier SM Infosite:www.smcavaliers.com

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    Quote Originally Posted by Karlin View Post
    Newly published paper from a research team including Penny Knowler and Dr Clare Rusbridge.

    Truly shocking figures -- in cavaliers with no symptoms, scans found SM already present in a FOURTH of all dogs by age 1 and 70% in dogs over 6.

    This means overall incidence in the breed is far higher than 70%, as this doesn't even include symptomatic dogs.

    How can any remaining doubting breeder now argue that this is not a widespread and serious problem

    This also reinforces the need for puppy buyers to check that parent cavaliers are over 2.5 years old when health tested and to check the health certificates for themselves.

    Remember that there can be no guarantees when buying a puppy but the best chance of avoiding early onset SM is by buying a cavalier with two grade A parents.
    Margaret C

    Cavaliers......Faith, The Ginger Tank and Woody.
    Japanese Chins.... Dandy, Benny, Bridgette and Hana.
    Remembered with love......... Tommy Tuppence and Fonzi

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    Definitely, especially as asymptomatic dogs are known to produce symptomatic dogs.
    Karlin
    Cavaliers: Jaspar Leo Lily Tansy Libby (foster) Mindy (foster)
    In memory: Lucy
    Cavalier SM Infosite:www.smcavaliers.com

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    Karlin
    Cavaliers: Jaspar Leo Lily Tansy Libby (foster) Mindy (foster)
    In memory: Lucy
    Cavalier SM Infosite:www.smcavaliers.com

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    The article points out a couple of bits of information as caveats to the reliability of the study:

    "First, the confidence limits for the OR [odds ratios] in the oldest group of animals were wide (because of the relatively small number of animals included within this group) and therefore must be considered less reliable. Secondly, although specifically excluded in terms of the present study, it is possible that the breeders may have included their dogs for the screening procedure while knowing that they expressed clinical signs of syringomyelia."

    Nevertheless, the conclusions to be drawn are powerful.

    First, the development of SM is progressive, and a SM-clear 12 month old could just be on the verge of a syrinx. Therefore, the older the dog at its first breeding, the better, and the closer that clear MRI to the breeding, the better.

    Second, if these dogs really were symptom-less, then these percentages are just a drop in the bucket, and the overall percentage is well over 70% of dogs at 6+ years.
    Rod Russell

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    Default STUDY of SM in 555 ASYMPTOMATIC CKCS:70% Affected by Age 6

    Quote Originally Posted by RodRussell View Post
    The article points out a couple of bits of information as caveats to the reliability of the study:

    "First, the confidence limits for the OR [odds ratios] in the oldest group of animals were wide (because of the relatively small number of animals included within this group) and therefore must be considered less reliable. Secondly, although specifically excluded in terms of the present study, it is possible that the breeders may have included their dogs for the screening procedure while knowing that they expressed clinical signs of syringomyelia."

    Nevertheless, the conclusions to be drawn are powerful.

    First, the development of SM is progressive, and a SM-clear 12 month old could just be on the verge of a syrinx. Therefore, the older the dog at its first breeding, the better, and the closer that clear MRI to the breeding, the better.

    Second, if these dogs really were symptom-less, then these percentages are just a drop in the bucket, and the overall percentage is well over 70% of dogs at 6+ years.

    STUDY OF SM in 555 ASYMPTOMATIC CKCS :70% AFFECTED BY AGE 6



    If there are according to Cavalier Registrations 90,000 Living at Ten Years of age here in Britain , 70 % at 6 that is Approx 63,000 Cavaliers .

    Then there is the figure of around 90% of Cavaliers suffering from CM which is Chacterized with Brains Too Big for the Skulls.

    No-Body can argue with the Results from this Veterinary Paper ,since it would be PEER REVIEWED

    Bet
    Bet (Hargreaves)

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    From reading Dr. Rusbridge blog http://clarerusbridge-news.blogspot....ome%20Research.

    Karlin, it looks to me like in the Netherlands almost doubled the amount of Cavaliers WITHOUT SM. Am I looking at it right? It say "Below is a graph showing a group of 380 CKCS which were screened for SM comparing the Netherlands to other countries in the world. Theinterim breeding guidelines were introduced in 2006 in the UK but breeders in Netherlands have been using them informally since 2004" So if I am looking at it right, something they are doing there (following protocols) has made a difference??? This is quite facinating since there is a large number of Cavaliers without symptoms.
    Anne Proud mother of Elton 5 and Angel Ella

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    Quote Originally Posted by anniemac View Post
    ... So if I am looking at it right, something they are doing there (following protocols) has made a difference??? ...
    That's what it looks like.
    Rod Russell

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    Truly devastating news

    Even with the caveats the odds are overwhelming - and there must be so many Cavaliers out their whose guardians do not recognise the symptoms still [or deliberately overlook them ] - too many suffering dogs.
    Nicki and the Cavalier Clan Our photos www.scotlandimagery.com
    Supporting www.rupertsfund.com and www.cavaliermatters.org

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    Hi

    A phrase is stuck in my head " suffer little chidren " they are our children and what have they done to deserve this .I am so sorry for our breed
    but I fell so mad when I hear people proclaiming

    If 'those people' would just let breeders concentrate on the job in hand, instead of us having to constantly defend what we do, or don't do with the knowledge we have collated from breeding, showing with success, and judging on a regular basis for between 30 & 40 years


    Is this what we are left with after these self proclaimed successful people of 30 and 40 years have fininished meddling with the breed, a total mess ,god help us and
    our Cavaliers.I can think of many people throughtout history who had this sort of self proclaimed ideology but I shall not put into print the ones I am thinking of .
    Ths news though expected is a crushing blow to all true Cavalier owners and essentially the many pet owners all around the globe .Legislation please ASAP
    to control these horrid people who breed with no thought for health,happiness and welfare nor the fuure only the attraction of those self glorifying CC and
    damn them too .
    Brian M

    Poppy the Tri, Daisy the Blen, Rosie the Ruby and Lily the B & T

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