Foetal tissue research has shown that there is a mismatch in the growth of the cavaliers skull v growth of brain, so in terms that I understand

this means that when the skull stops growing, the brain continues to grow for a bit longer, instead of what should happen ie: when bones in skull stop growing, the brain should do also.
So to my simple mind - if this is the case, it wouldn't make any difference whether you tried to breed Cavaliers the size of Great Danes, until the faulty genes are found that control the brain/skull growth you would still have the problem of not enough room at the back of the skull - in a much bigger dog. That's how I undertand it anyway.
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