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Thread: Free DNA tests not being taken up. Notice from the Cavalier Club website

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    Default Free DNA tests not being taken up. Notice from the Cavalier Club website

    I am pleased to see the Cavalier Club are trying to get breeders to take up this very generous offer from the AHT.
    They are offering 200 free DNA tests for Dry Eye/Curly Coat & Episodic Falling Syndrome but it would seem that club members are reluctant to find out whether their cavaliers are carriers ( even though they can still be bred to non-carriers )

    I suppose old attitudes die hard but I am surprised to see this sentence included.................

    "Many of you have felt that the statiscal picture for the incidence of CM/SM in our breed is warped by the number of unhealthy Cavaliers submitted."

    The notice writer really should have pointed out that belief has no basis in fact, as most of the peer reviewed published studies have been on asymptomatic cavaliers that the breeders themselves have taken to the low cost scans.

    The website notice reads...........


    CALLING ALL BREEDERS

    We are being given the opportunity – and for a change – at no cost to us – to provide ACCURATE statistics for the incidence of Dry Eye/Curly Coat Syndrome and Episodic Falling. As responsible breeders there are no excuses as to why you cannot submit a cheek swab – there are no risks; there is no anaesthetic or sedation. All that willing participants need to do is submit the name of their dog or bitch to Annette Jones (email Club Health Representative or phone 01490 430554) who is compiling a list. You may think that your Cavalier’s breeding is not unique – JUST PUT THE NAME FORWARD. One Cavalier born after 2005 per breeder – the cost would normally be £48 and this has been waived. (If you require a certificate there is a £10 charge.)

    Many of you have felt that the statiscal picture for the incidence of CM/SM in our breed is warped by the number of unhealthy Cavaliers submitted. You have an opportunity to produce an accurate picture. THE INDIVIDUAL RESULTS from this project will be STRICTLY CONFIDENTIAL.

    This is important please don’t ignore this request. For full information please read the AHT Study details.
    Margaret C

    Cavaliers......Faith, The Ginger Tank and Woody.
    Japanese Chins.... Dandy, Benny, Bridgette and Hana.
    Remembered with love......... Tommy Tuppence and Fonzi

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    I do wonder what Jacques Penderis, the researcher who worked to create this test and who is the leading authority on Episodic Falling and who has tested many many dogs, would think of that bizarre statement that level of affectedness is based only on a mostly symptomatic test sample! It certainly seems thoughtless and rude to phrase this particular request in this way on the website -- who else can the people who posted it men but the very researchers at the AHT who have worked for years to give them this test?

    I've never actually seen anyone claim any particular rate of incidence for Curly Coat so not sure what they can mean about its incidence being overestimated . While it isn't high, going from reports, it is significant in the breed, and devastating for dog and owners and breeders. Surely breeders would be overjoyed at having a simple test to detect it? Yet so few in the UK have tested their dogs -- seems a much larger takeup from vets seeking a diagnosis and breeders from abroad.

    Without testing, breeders won't have any idea of what they are dealing with. Penderis told me that in the large sample of dogs they tested and in dogs he sees, the gene for EFS is very prevalent and much higher than epilepsy.

    I do remember it was not so long ago that some breeders and their 'health websites' were stating that rate of SM to be 0.02% in the breed --even on a US national club website -- at a time when researcher estimates were consistently showing at least 30-40% and likely higher. And now it is accepted to be in the realm of 70% by age 6+.
    Karlin
    Cavaliers: Jaspar Leo Lily Tansy Libby (foster) Mindy (foster)
    In memory: Lucy
    Cavalier SM Infosite:www.smcavaliers.com

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    Default From the Cavalier Health Liaison Committee website. Perhaps we can help?

    Dogs required for study

    The Animal Health Trust (AHT) recently launched a combined DNA test for dry eye and curly coat syndrome and episodic falling in Cavalier King Charles Spaniels. As an additional service to the breed, we intend to estimate the frequency of mutant alleles for both conditions in the UK population. This would involve collecting DNA samples from 200 individual dogs of breeding age, widely selected to be as representative of the population as possible so that the mutant allele frequencies of both of these conditions can be determined with some degree of accuracy. Genotyping will be performed in the AHT laboratory once all 200 samples have been submitted. The standard £48 fee for the combined test will be waived for participating dogs, and owners will not be charged for email notification of their dog's results. A certificate can be sent to owners on request for a £10 fee to cover administrative costs. Individual test results will remain confidential. Once data analysis is complete, a report summarising the overall findings will be sent to you for distribution to the participating breed clubs and other interested parties. The guidelines for selection of participating dogs are as follows: • each of the 200 dogs should have a unique dam • ideally, each dog would also have a unique sire, but as this may be difficult to achieve we ask that no more than four dogs out of the total 200 share any one sire • only one dog can be tested free of charge per owner • dogs must have been born on or after 1st July 2005 • dogs must be registered with the UK Kennel Club To register your interest in participating in this study, please contact Peter Towse, kchealthrep@cavalierhealth.co.uk. Providing the name, date of birth, KC registration number, microchip #, sex, colour, sire and dam of the dog you would like to participate in the study. Then your name, address, telephone and email address. If your dog does test positive, it is NOT a failure, it’s a carrier and can still be bred from. Knowing its status you don't bred to another carrier.



    Well done to the Cavalier Health Liaison Committee for following the Cavalier Club's lead and putting this notice on their website.

    It will not be eay for the cavalier clubs to find this number of dogs. Club members tend to use a fairly limited number of show bred stud dogs so to find 50 separate sires will not be simple.

    This is a study where pet owners may be able to help.

    Please note that it does not say you must belong to a cavalier club, only that you have a Kennel Club registered dog that is microchipped and born before July 2005.

    Although the DNA tests are designed to help breeders, in this case the free test is being made available so that the researchers can estimate how many cavaliers carry the genes that cause these two inherited conditions, so I imagine you can consider putting your cavalier forward even if it is neutered or spayed.

    The free test will just require swabs on sticks being rubbed on the inside of your pet's mouth ( it really is easy, I have done it with Faith )

    Forum members in the UK could offer to help make up the numbers of cavaliers required for this study & demonstrate their practical support for research into breed health, so please consider emailing the contact address above if you have a cavalier that is eligible.

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    Hello Margaret

    Daisy has just read this and asked me to mail Mr Towse which I shall do
    in the morning.


    Best Wishes

    Daisy and me
    Brian M

    Poppy the Tri, Daisy the Blen, Rosie the Ruby and Lily the B & T

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    And what about Rosie who says she's just as posh as Dangerous Daisy?
    Mustn't forget the wholecolours?
    If she were mine I would choose that one as possibly the most useful.
    What some people are doing is putting forward a number of dogs and letting the coordinators have their choice.
    No harm offering the entire quartet?
    Sins

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    Hi Sins

    After a group discussion it has been passed one for all and so we are all in ,so me being
    the carer and handy slave will get all their paper out and send it all off tomorrow ,pity
    I am not KC reg being a Murtagh O Brian as you know .
    Brian M

    Poppy the Tri, Daisy the Blen, Rosie the Ruby and Lily the B & T

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    Sounds like that could be IKC reg Bri .
    Sins

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    Quote Originally Posted by sins View Post
    And what about Rosie who says she's just as posh as Dangerous Daisy?
    Mustn't forget the wholecolours?
    If she were mine I would choose that one as possibly the most useful.
    What some people are doing is putting forward a number of dogs and letting the coordinators have their choice.
    No harm offering the entire quartet?
    Sins
    Great idea. A few more owners like Brian & the problem would be sorted.

    What about you Sins? Are you putting your UK girls forward or have both their parents already been checked?
    Margaret C

    Cavaliers......Faith, The Ginger Tank and Woody.
    Japanese Chins.... Dandy, Benny, Bridgette and Hana.
    Remembered with love......... Tommy Tuppence and Fonzi

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    Hi Margaret,
    Holly has already been tested and is clear.Ivy has the same sire as Holly and her dam is clear.
    I could offer Ivy I guess..the sire himself has been put forward.The dam has three clear offspring but has a fairly popular sire...on the club website it says one cavalier per breeder born after 2005 so she may be too old to be eligible,but I believe the breeders have offered some of the younger ones.
    I know of some breeders with small kennels who have already had all their dogs done and if this random testing doesn't happen reasonably quickly,I think many breeders who are interested will go ahead and test if the dogs are needed for breeding.
    Sins

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    Quote Originally Posted by sins View Post
    Hi Margaret,
    Holly has already been tested and is clear.Ivy has the same sire as Holly and her dam is clear.
    I could offer Ivy I guess..the sire himself has been put forward.The dam has three clear offspring but has a fairly popular sire...on the club website it says one cavalier per breeder born after 2005 so she may be too old to be eligible,but I believe the breeders have offered some of the younger ones.
    I know of some breeders with small kennels who have already had all their dogs done and if this random testing doesn't happen reasonably quickly,I think many breeders who are interested will go ahead and test if the dogs are needed for breeding.
    Sins
    It is wonderful to think that in future there will be no reason for these two distressing conditions to affect any cavaliers that are bought from a well informed cavalier club breeder.

    Even if the free tests are delayed, £48 is not too much to pay for a one-off test that will enable a breeder to say with confidence that their puppies will not have DE/CC or EFS.

    The obvious solution would be for the KC to be sending information about this test, and the free offer, out with registration papers. That might get the AHT better range of cavaliers from non-show lines as well as show bred dogs and make the results more representative of the whole cavalier population.

    Non cavalier club breeders have no way of knowing about recent health testing developments such as these DNA tests or the forthcoming BVA/KC MRI scanning scheme.

    Health campaigners have long urged the KC to send out health information with their registration paperwork. The KC make vague promises and say that they are piloting schemes, but it just does not seem to happen.
    Margaret C

    Cavaliers......Faith, The Ginger Tank and Woody.
    Japanese Chins.... Dandy, Benny, Bridgette and Hana.
    Remembered with love......... Tommy Tuppence and Fonzi

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