One of the main causes of corneal degeneration is lipid (fat) deposits in the supporting structure of the inner eyeball: the stroma and the epithelium. While lipids are a normal part of the body, being, as they are, a principal structure of living cells, hyper deposits of lipids in the tissues can bring about disorders to the system they are inhabiting. Systemic hyperlipoproteinemia, a metabolic disorder characterized by elevated concentrations of cholesterol and specific lipoprotein particles in the blood plasma, may increase the risk of deposits in the stroma, or may worsen already existing deposits. Hyperlipoproteinemia can be secondary to hypothyroidism, diabetes mellitus, hyperadrenocorticism (chronic production of too much cortisone), pancreatitis, nephrotic syndrome (a disorder in which the kidneys are damaged), and liver disease.
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