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Thread: Swabs - DNA testing, Van Andel Research Institute

  1. #1
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    Default Swabs - DNA testing, Van Andel Research Institute

    Calling ALL Cavaliers to unite ask your owners/people to give 100% participation & pass this info on to others. I encourage all breeders to not only cheek swab their dogs they own, but to contact all of their pet owners in asking them to do the same.
    Doctors who see Cavaliers for these health issues to pass this info on to owners. I think we can form a village to help move this mountain by giving support in getting these ...cheek swabs done. Please read how you can help.
    There is a group of researchers who are investigating the genetics behind Cavalier health issues. We are asking for your help and support at no cost to you. Post this to your FB, I have on Jill Scan. I condensed the info into a doc below.
    The group is Van Andel Research Institute in Michigan and they are working on Cavalier genetics for SM, MVD, and early hearing loss. They were working on only hearing loss in the Cavalier, but have expanded their efforts to included SM, MVD & early hearing loss.
    They are a non-profit and the tests (cheek swabs) they need to do the research are free.
    This is a call out to ALL owners of a Cavalier to rise to the occasion to support this research. This is vesting just a wee bit of time to protect preserve the love this breed gives so freely to us. Please read below as to how you can help and FAQ.

    1-1st is to E-mail to Linda see #11 below to get swabs for your dog(s) AND send this on to any others for them to participate.

    2- You will also be automatically added to their database and get updates on how things are progressing.
    If/when they locate the genes controlling these diseases you will automatically be sent the results for your dog(s).
    (This can directly benefit one's breeding program and the future of Cavaliers)

    3-Your dogs’ identities will be protected.

    4-There are no age limits, as long as the dogs are weaned.

    5-It does not matter where the dog is, in what country, it's breeding/pedigree, registration etc.

    6-They need swabs from a total of 1000 Cavaliers, including ones that have been MRI’d clear, and those that have been MRI’d with SM, as well as bunches of “unknowns” or unscanned dogs.

    7- If your dog is deaf or hard of hearing, make mention of this in your e-ml to let Linda know, she will send you a special kit for those dogs. It's a different collection for hearing.

    8- You will fill out a short questionnaire that will be emailed to them in about the first of September. The questionnaire should take less than 10 minutes for each dog that a swab was sent in on.

    9- All individual results are confidential!

    10- A bonus is that everyone that sends in swabs now those dogs their genetic code will be in that database and as results become available for markers could qualify for additional free testing, and results prior to the final publishing of the marker.

    11- E-ml Linda lynwoodstudio@yahoo.com and request the quantity of swabs needed for your Cavaliers. Be sure to include your name, email, mailing address along with the quantity of swabs needed.

    12- Be sure to include on each dog’s cheek swab as to how this dog fits into the goals outlined below, include identification of that dog name & registration # DOB owner’s name written on the label for each cheek swab. More info is better than not enough. The reason is if the research team has any question they know which DNA they are needing more information on and also will help them to know at a glance what group this dog’s DNA fits into as to the parameters they are looking for to compare in trying to find the genetic mutation.

    There are already participants from Canada, Australia, Alaska, and I believe England. The more the better to get as much diversity & get the #’s for the genetic profiling they need below. This group is well versed in canine genetics and has discovered the genetic links for diseases in other breeds of dogs.

    Some further info on this research team from Linda:
    All Clumber spaniels breeders bank DNA for research with them. A Clumber breeder/judge at the CKCS national took enough swabs back to Alaska for Cavalier owners because of Van Andels great help in Clumbers. I spoke with this Clumber person who impressed upon me their work. She did not expound on specifics but said that Van Andel's research saved her breeding program!! Talk about a passionate believer! This is even more motivation for us to make sure we get our Cavaliers into their research. The more I learn of this research group, the more I am so impressed!

    Linda is a volunteer contact person for cavaliers and not affiliated with Van Andel nor has any interest other than is a CKCS breeder that knows this needs to be done
    Again, I can not thank you enough. We have nothing to lose and everything to gain. The plus side is that we, as the participants could gain valuable genetic information free of charge and it is confidential!
    Goal:
    1,000 general population cavalier swabs across the US

    100 early onset hearing loss

    100 MVD clear

    100 with MVD

    100 MRI cleared of SM

    100 symptomatic of SM

    Fully Weaned puppies to geriatrics. As you see, all cavaliers qualify! There is simply no reason to not do this.

    If your dog is deaf or hard of hearing, let Linda know and she will send you a special kit for those dogs. It's a different collection.

    With all my heartfelt thanks, for doing a good thing for the dogs & their future,
    Linda Baird Lynwood Cavaliers

    Please email Linda at lynwoodstudio@yahoo.com and request the swabs for any Cavaliers you have see #11 above for the info needed to include.
    It’s a chance to get some real data about these awful conditions. For anyone who has lost a loved dog to one of these conditions this is a way to remember them, to try to help the dogs now and in the future.




    This is the original webpage for the hearing loss scheme which has now been extended
    http://www.vai.org/Research/Labs/Neu...g-Charles.aspx
    Nicki and the Cavalier Clan Our photos www.scotlandimagery.com
    Supporting www.rupertsfund.com and www.cavaliermatters.org

  2. #2
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    Will do especially since my puppy comes from unknown, the pregnant mother was dumped at a shelter. I'm all about helping research and this sounds so easy.

    Melissa


    Actually Nicki all I did was hit the orginial web site link on the bottom of your post they have all the info there and you can request the kit right there. Super easy!! Already done.

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    Would be more than happy to participate in any way that I can. Will have to read the details tomorrow when on the PC and send off an email, so count me in.

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    If they are a rescue and we don't know genetics, can they participate or no?

    I'll email later for Lucky but wondered if Sparky can participate too since he's a mill rescue and I know nothing of his parents or lines.
    Lani
    (a.k.a. Lucky's & Sparky's mom!)

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    I am going to email them for further detail on the SM side -- a dog 'clear' of SM might have MRId years ago as 'clear' and now have it -- they don't ask for recently scanned clear. Nor is there any information on how they will analyze/standardise the supposed 'clears' -- some neurologists and radiologists internationally have given dogs a 'clear' that have actually had syrinxes or pre-syrinxes (this issue of a standardised read was a HUGE issue for breeders in planning the BVA/SM scheme -- it should be a concern here as well. With the BVA/KC SM scheme, a panel of three neurologist experts in SM adjudicate on scans; none is accepted simply by the analysis it comes in with from a neurologist or radiologist and that scheme needs less precision than research for a DNA test would need). And what about CM, which is almost definitely closely associated? I wonder if they are aware of the work done so far, which does take into account both CM and SM?

    I welcome this work especially on deafness (which WAY too many cavaliers have ) as well as MVD, which is easier to analyze than SM. But unless the SM side takes into account all these details, I think it will be meaningless.
    Karlin
    Cavaliers: Jaspar Leo Lily Tansy Libby (foster) Mindy (foster)
    In memory: Lucy
    Cavalier SM Infosite:www.smcavaliers.com

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    [QUOTE

    Goal:
    1,000 general population cavalier swabs across the US

    100 early onset hearing loss

    100 MVD clear

    100 with MVD

    100 MRI cleared of SM

    100 symptomatic of SM [/QUOTE]

    And all of these categories are based on self-identification? Never heard of a valid study being conducted in this manner.

    Pat
    Pat B
    Atlanta, GA

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    Quote Originally Posted by Pat View Post
    ... And all of these categories are based on self-identification? Never heard of a valid study being conducted in this manner.
    Yes, odd.

    Here are a couple of links directly to the researchers' websites. Another odd thing is that neither of them mention these studies, beyond hearing loss in the breed.

    http://www.tgen.org/research/index.cfm?pageid=1484

    http://www.vai.org/Research/Labs/Neu...g-Charles.aspx
    Last edited by RodRussell; 7th May 2012 at 03:27 PM.
    Rod Russell

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    Don't have the time or inclination to research this in depth - but this sounds like that ACKCSC survey done some years back - only with cheek swabs! (That's the study that indicated SM was in 2% of the breed.)

    I'm tempted to quote my favorite doctor, Gregory House..........but in this case I think it's not so much that everyone lies but more that I have no reason to accept self-identified health status "facts" from pet owners - we (and I include myself) just don't have the credentials to make these black and white pronouncements (my dog is MVD clear versus has a trivial leak but no audible murmur, for example) for a valid research project........which is why valid research projects use different criteria that is far more stringent.

    Pat
    Pat B
    Atlanta, GA

  9. #9
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    If you just check out this web site you can order the kit. Took me like 2 seconds. Nicki's right why not???

    This is the original webpage for the hearing loss scheme which has now been extended http://www.vai.org/Research/Labs/Neu...g-Charles.aspx


    Melissa

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    Quote Originally Posted by Pat View Post
    Don't have the time or inclination to research this in depth - but this sounds like that ACKCSC survey done some years back - only with cheek swabs! (That's the study that indicated SM was in 2% of the breed.) ...
    The most valuable thing I learned from that survey -- http://ackcsc.org/images/stories/pd_...inalreport.pdf -- was information about the dangers of walking dogs on grass treated with pesticides and other chemicals. That was because the survey was conducted by Purdue's clinical epidemiology professor, Dr. Larry Glickman.

    That was when I stopped running my dogs on the golf course behind my house.
    Rod Russell

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