21st September 2012, 10:34 PM
omeprazole and cimetidine
The algorithm (sp) on C. Rusbridge's website refers to those two drugs so I Googled to see what they are used for and found they are for stomach acid. What is the connection with SM and neurological pain?
22nd September 2012, 02:35 PM
This is from http://cavalierhealth.org/syringomyelia.htm#--_drugs
Originally Posted by rubles
Drugs which reduce the production of cerebrospinal fluid, including proton pump inhibitors such as omeprazole (Prilosec, Losec, Omesec, Zegerid), and the diuretics, furosemide (Lasix, Diuride, Frudix, Frusemide) and spironolactone (Aldactone), are reported to be useful to reduce intracranial pressure. Long term use of omeprazole is not recommended by some neurologists, as its long term use reportedly has increased the risk of stomach cancer in lab rats. Short term use reportedly can cause a "profound and sustained increase in serum gastrin concentration in dogs." See June 2011 report.
Cimetidine (Tagamet, Zitac), which is a histamine H2-receptor antagonist -- an antihistamine. Histamine contributes to inflammation and causes smooth muscles to constrict. Cimetidine is diffused into the cerebrospinal fluid and reportedly may contribute to reducing the flow of CSF. When taken with gabapentin, cimetidine also reportedly may increase the amount of gabapentin in the blood by decreasing its elimination. Therefore, when taken together, the dosages may require adjustment.
23rd September 2012, 12:48 AM
I've got a lot to learn.