In an editorial in an upcoming issue of the Veterinary Journal, Dr. Jacques Penderis gives a grim estimate of the chances of breeding Chiari-like malformation out of future generations of cavalier King Charles spaniels. He views cavaliers' high prevalence of CM and limited genetic diversity as "major difficulties" in breeding away from CM in the future.

Details at http://www.cavalierhealth.org/syring...etic_diversity