In a just-released report by leading UK CM/SM researchers, they studied the clinical signs of neuropathic pain in 48 cavalier King Charles spaniels for a mean average of over a three year period. Nine of the 48 dogs had only CM. None had been treated surgically. They found that the clinical signs suggest that neuropathic pain progressed in 75% of the dogs with either CM/SM or just CM. They noted that it is not fully understood how CM/SM causes neuropathic pain, and that their study does not make any such finding.

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