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Thread: Liquid Gabapentin Contains Xylitol - Toxic to Dogs

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  1. #1
    Join Date
    Mar 2005
    Atlanta, GA
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    Default Liquid Gabapentin Contains Xylitol - Toxic to Dogs

    When I was checking to see how many mg. of Gabapentin are in each ml of oral solution, I found that the oral solution contains xylitol. This is very important to know if you are considering using the liquid. See info and links below:


    Gabapentin Oral Solution
    250 mg / 5 mL

    The inactive ingredients for the oral solution are anise flavor, artificial strawberry flavor, glycerin, hydrochloric acid, purified water, sodium hydroxide and xylitol.

    Gabapentin in a Xylitol-Free Formulation

    Gabapentin is only approved for use in humans, but is widely used in veterinary medicine for both analgesia and neuroleptic indications. Dosed at 10-15mg/kg orally up to three times daily, this drug has become a valuable adjunct in veterinary therapies. Historically, gabapentin was available as a 100 mg scored tablet, enabling dosing of small animals (e.g. those weighing 5 kg or less) by quartering or halving tablets. Recently, gabapentin 100 mg tablets have been discontinued by all manufacturers, resulting in gabapentin 100 mg capsules being the smallest solid dosage form of gabapentin on the market. Because these capsules cannot be easily divided into smaller doses by pet owners, veterinarians have considered using Neurontin (gabapentin) 50mg/ml oral solution to dose smaller patients. Unfortunately, Neurontin Solution contains 300mg/ml of xylitol, an artificial sweetener which is known to cause profound hypoglycemia and hepatic necrosis in dogs at single doses of 100mg/kg. Dogs receiving doses of 0.3ml/kg of Neurontin daily will be exposed to potentially toxic doses of xylitol. For this reason, veterinarians are turning to compounding pharmacists to compound patient-specific doses of gabapentin in capsules or treats, or compounded suspensions of gabapentin that do not contain xylitol.
    Last edited by Pat; 20th March 2013 at 07:11 PM.
    Pat B
    Atlanta, GA


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