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Thread: Liquid Gabapentin Contains Xylitol - Toxic to Dogs

  1. #1
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    Default Liquid Gabapentin Contains Xylitol - Toxic to Dogs

    When I was checking to see how many mg. of Gabapentin are in each ml of oral solution, I found that the oral solution contains xylitol. This is very important to know if you are considering using the liquid. See info and links below:

    Pat


    Gabapentin Oral Solution
    250 mg / 5 mL

    The inactive ingredients for the oral solution are anise flavor, artificial strawberry flavor, glycerin, hydrochloric acid, purified water, sodium hydroxide and xylitol.

    http://www.drugs.com/pro/gabapentin-oral-solution.html

    http://www.empr.com/fda-approves-gen...ticle/240816/#

    http://commissionerspharmacy.com/pha.../vet_pain.html


    Gabapentin in a Xylitol-Free Formulation

    Gabapentin is only approved for use in humans, but is widely used in veterinary medicine for both analgesia and neuroleptic indications. Dosed at 10-15mg/kg orally up to three times daily, this drug has become a valuable adjunct in veterinary therapies. Historically, gabapentin was available as a 100 mg scored tablet, enabling dosing of small animals (e.g. those weighing 5 kg or less) by quartering or halving tablets. Recently, gabapentin 100 mg tablets have been discontinued by all manufacturers, resulting in gabapentin 100 mg capsules being the smallest solid dosage form of gabapentin on the market. Because these capsules cannot be easily divided into smaller doses by pet owners, veterinarians have considered using Neurontin (gabapentin) 50mg/ml oral solution to dose smaller patients. Unfortunately, Neurontin Solution contains 300mg/ml of xylitol, an artificial sweetener which is known to cause profound hypoglycemia and hepatic necrosis in dogs at single doses of 100mg/kg. Dogs receiving doses of 0.3ml/kg of Neurontin daily will be exposed to potentially toxic doses of xylitol. For this reason, veterinarians are turning to compounding pharmacists to compound patient-specific doses of gabapentin in capsules or treats, or compounded suspensions of gabapentin that do not contain xylitol.


    http://www.vcahospitals.com/main/pet...y-in-dogs/4340


    http://www.healthypet.com/PetCare/Pe...xicity_in_dogs
    Last edited by Pat; 20th March 2013 at 07:11 PM.
    Pat B
    Atlanta, GA

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    Quote Originally Posted by pat View Post
    ... Unfortunately, neurontin solution contains 300mg/ml of xylitol, an artificial sweetener which is known to cause profound hypoglycemia and hepatic necrosis in dogs at single doses of 100mg/kg. Dogs receiving doses of 0.3ml/kg of neurontin daily will be exposed to potentially toxic doses of xylitol. ...
    yikes!!!
    Rod Russell

  3. #3
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    My neurologist said the Gabapentin she supplies me with does not contain Xylitol but if you get it from a regular pharmacy like CVS or Walgreens then it does contain Xylitol because its flavored for children.

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    When Sadie had to be on liquid Gabapentin due to the dosage she needed at the time, we had to go to a compounding pharmacy and have it specially made for her so that it wouldn't contain Xylitol.
    -Teri
    Mom to Joey and Sadie (9 yr old Blenheims)
    Washington State, USA

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    The gabapentin Charlie was prescribed at the drugstore tasted bitter--I sampled it. This prescription formed clots and sediment. The prescription from the vet college tasted bitter, was prescribed with a shelf life of two weeks. It was a relief to be able to administer 100mls capsules.

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