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So sick--Please help!!

To give everyone an update, Charlie is doing about the same...still just lays there, still not moving much. He ate his food today with slightly more interest, actually licking up some of it himself. He will sometimes drink from the bowl if you hold it up to his mouth. He has not gotten up on his own yet, but he has kind of half-sat up a couple of times when Chris came near him. (He just adores the man...he's got great taste!). We're hoping that these might be signs of improvement, but it's just really hard to tell. Charlie is still nothing like the bouncy, hyper, happy boy he usually is. It's really, really hard to see him like this.

We talked to Charlie's internal specialist today. He did think that Charlie sounds a bit improved, but he was definitely hoping for a more apparent change in movement and behavior. The lepto test hasn't come back yet, but he thinks we should know in the next couple of days. The urine cultures came back negative for bacterial infection, though, so if it's not lepto, then it's probably an autoimmune problem. The doctor mentioned immune-mediated polyarthritis several times on the phone, so I think that's his thinking. This was already on my own list of possibilities, so I wasn't that surprised.

If this is the case, Charlie would have to be put on high-dose Prednisone to see if his disease could go into clinical remission....if so, they would wean him off the steroids with the hopes that he would stay well. The problem with all of this is that if we are dealing with autoimmune disease, the doctor said that with Charlie being so young, he would very likely have several periods of regression throughout his life. He would have to go back on the high-dose steroids every time he showed symptoms. The doctor described it as a steroid rollercoaster, with many potential side effects. He said that Charlie would have less energy, and would very likely become overweight and develop diabetes.

This is all very hard to swallow. Charlie is only a year old. He's a high-energy, fun-loving dog. He loves to chase squirrels, chase his ball, chase the kids, and take LOOOONG walks. He's like the Energizer Bunny of Cavaliers! It's really hard to picture him as a more placid dog, and it's painful to think of him as a sickly dog his whole life. I'm trying to do a lot of reading about autoimmune disorders to get a good picture of what Charlie's life would be like, but it's difficult, because most of what's available to read is clinical studies and journal articles. We don't yet know what is best for Charlie if this is what we're dealing with....so we're still hoping for the lepto test to come back positive.

If anyone here knows anything about autoimmune disorders, or has had a pet with a similar disease, we would of course love to gain any knowledge we can on the subject...it's really hard not knowing what to do for the pet you love. Thank you all for your continued support and prayers...Chris and I both gain strength from hearing your kind words.

-Andrea
 
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Andrea, so sorry that this just drags on and on for you with no end in sight. I don't have any advice since I thankfully haven't experienced what you are going through, but I might make a suggestion. If you start a new thread and title it something like "possible autoimmune disease in Charlie-help!" it would get the attention of anyone who has experience with this type of thing and I am sure they would be quick to help with all the knowledge and experience they have.

I will continue to be pulling for you. :xfngr:
 
Sorry to hear that Charlie is not improving as fast as we had all hoped. I guess tiny steps are at least progress though.

There is a lady who has been at the forefront of dealing with and publicising auto immune issues in Bearded Collies. She *may* be able to help or could perhaps poimt you towards correct information.

This is the only contact I can find for her

Jo Tucker -

[email protected]

Otherwise I know Beverly Cuddy of Dogs Today magazine has had dealings with her and may put you in touch.
 
I have been reading your thread & waiting for some good news. Glad to hear there is some improvement. You and Charlie will continue to be in my thoughts & prayers.
 
one of the guys I work with had an autoimmune issue a couple years back that cause the muscles in his legs to seize up, sounds like what your charlie has, he was over it in a couple of weeks. I hope charlie gets better soon!
 
I only just read this thread (completely) and I'm so sorry for all of you :( I can't even imagine how I would feel if something like that would happen to any of our cavaliers... I even panick when they just got the flu or something stupid..
So I can only say that you're really very brave and I honestly hope that there will be a change in the very near future!
I'll be thinking of all of you and crossing my fingers!!!
 
Andrea: Worried about my baby also but you are also in my mind. Please keep posting about Charlie. We haven't heard anything from you in about 36 hrs. so please post even if no change etc. We care!!!
 
Charlie is still doing about the same. He still can't walk, and still just lays there not moving much. His appetite does seem to be a bit better...basically, Chris offers him a bite of the prescription mushy food, and Charlie licks it up. This is definitely easier than physically putting the food in his mouth, and we are hoping it's a sign that Charlie is feeling a bit better. The no walking thing is very worrying, though, as Charlie's internist said we should be seeing a lot more movement by this point if we're dealing with an infection. We left a message with the doctor with the hopes that he'll call us with the Lepto test results today, but it's possible we won't know until tomorrow. :xfngr::xfngr::xfngr: for a Lepto diagnosis. I'm finding out as much as possible about autoimmune disease and Prednisone just to be prepared in case we don't get the result we're hoping for. We really love this little pup, and his quality of life is the most important thing we have to consider.

Thanks to everyone here, and we'll let you know as soon as we know.
-Andrea
 
Hi Andrea,
thanks for keeping us updated. Still praying for a Lepto diagnosis and a good outcome for you all.
 
Thanks for the update..still hoping for a good outcome and sending positive thoughts for charlie.
 
I know your family is really going through a lot right now but know that everyone on this board truly cares and is praying for Charlie.
 
I hope all is well still.its hard i know,i just lost my boy,he was nearly 3.We had a rapid decline after ear surgery.Jus.
 
Well, we heard back from Charlie's internist today, and the Lepto test came back negative. This means that Charlie has been diagnosed with autoimmune disease. Specifically, Dr. Wasik said that he is relatively certain Charlie has what is known as Immune-mediated Polyarthritis. What this means is that Charlie's immune system, for reasons still unknown, went nutty and attacked his joints with massive inflammation, leaving him with major arthritis in multiple joints. All of the other symptoms that Charlie experienced were due to his body tricking itself into thinking that he was very sick, hence the fever, loss of appetite, no energy, etc.

The prognosis for this disorder is...complicated. Charlie is starting high-dose Prednisone (steroid) tonight. What we have to do is suppress his immune system enough that the autoimmune reaction "turns off" so that the inflammation will go away and Charlie will feel better again. If all goes well, Charlie should show major improvement in just a couple of days, and should feel well within a couple of weeks. If his body goes back to "normal", then we will slowly taper back the Prednisone with the hopes that he stays stable. If he remains well, he will be able to go off the meds completely. At that point, Charlie should feel great and be himself again; his disease will be in remission.

It is possible that once in remission, he might never have symptoms again. It is probable that he will relapse at some point, however, and he will have to go back on the Prednisone right away to try to keep the arthritis from setting in again. The doctor said that it is very possible that Charlie could have multiple relapses in his lifetime. And it is unfortunately also possible that the disease will not fully reach remission, in which case Charlie would have to stay on the Prednisone long-term or take other, more powerful drugs.

This is all very scary to us. We are putting this little guy on major meds and we don't even know for absolute certain that this disease is what he has. And obviously, it's extremely upsetting to find out that your sweet little dog has an incurable disorder like this. We have been going through all of this for a month now, and I feel like I've been in shock the whole time. We want Charlie to have a great life, and this all just seems like a big roll of the dice.

But, Charlie is doing all right. He still mostly just lays there, but from time to time he seems more alert. He had a decent appetite today, eating all of his food with no fuss. And he's been drinking more, so I'm sure that makes him feel better. His walking is not really improved, but he did get up on his own for a minute yesterday. And he wagged his tail for the first time in four weeks! (It was only for a second, but I nearly cried). The doctor said that these little improvements give him hope that Charlie might improve really quickly once his immune system is suppressed. So that's what we're hoping and praying for now. Thanks to all of you for helping us through this difficult time, and I hope that we'll have better news to report in a day or two.

-Andrea
 
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I hope little Charlie continues to improve. At least you know what your dealing with now, and can go from there. Just know that we are all praying for you and Charlie and miracles do happen, so he could turn the corner and be your happy little baby again. Please keep us posted on his progress.:flwr:
 
Andrea, I am sorry to hear that your situation with Charlie is going to be such an ordeal for the duration of his life, but he is a lucky boy to have a "mommy" like you to make sure he gets everything he needs.

I guess as bad as it is, feeling like you are getting somewhere with a diagnosis must help some. I know for me, the waiting is worse than the knowing.

I will hope to see that he improves rapidly and that he never has a relapse.
 
Sorry that Charlie has come under autoimmune disease as a solution . Sometimes diagnosis is achieved by rule-out-that is rule out everything else. The Yahoo clubs possibly have one devoted to autoimmune disease and some-times valuable tips can be gleaned but you do have to wean out the "chaff". One of the thoughts down the road will be about vaccines and whether or not to have them administered-Dr.Jean Dodd, online, has information about vaccines and the immune system. And now-the best-Charlie back to a bouncing smiling Cavalier boy ready and able to tackle his world :rah:. Know that he could have a double Cavalier attitude re: food when he is on steroids -they could easily increase his appetite to no end. I hope he responds to the treatment so well that you can smile all day.:luv:
 
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