4June 2007: Association between frontal-sinus size and SM: Dr. Dewey and others (Drs. Peter V. Scrivani, Margret S. Thompson, Kevin R. Winegardner, and Janet M. Scarlett) report in a June 2007 article of a study of 62 dogs (four of them were CKCSs) that there may be an association between frontal-sinus size and SM in Cavaliers and other small-breed dogs. They state: "Our data do suggest, however, that the pathogenesis of syringohydromyelia in small-breed dogs may involve the supratentorial portion of the cranial cavity. We postulate that syringohydromyelia develops in many small-breed dogs and certain breeds in particular as a result of global malformation of the entire cranial cavity or supratentorial portion of the cavity and is not limited to the infratentorial portion of the cranial cavity. If this is true and results can be generalized to the target population, our understanding of the pathogenesis of syringohydromyelia in small-breed dogs and several aspects of clinical management (e.g., screening and diagnostic testing, breeding recommendations for dogs with dome-shaped heads, and treatments) will require further investigation."
4May 2007: Study of possible correlation between head shape and CM/SM in Cavaliers and other toy breeds. Dr. Rusbridge and Ms. Knowler report in their April/May 2007 Research Newsletter the the preliminary results of pilot study looking at the possible correlation between head shape and CM/SM in different toy breeds. They report: "In response to some observations made by breeders on head shape, a simple pilot study was devised. Dogs were selected on the basis of head length/breadth ratio, degree of doming, and presence or absence of a ski-slope shape to the back of the head. CM/SM status was confirmed by MRI. Early results of this pilot study found no correlation, however the investigation is still ongoing. This study has been a tremendously valuable exercise in other ways. On the basis of head shape, some dogs had been presumed to be affected, and owners had originally elected against MRI screening. However some of these dogs were actually found to be free of the condition. This suggests that it is not yet possible to predict CM/SM by a visual assessment of head shape. It also provided the opportunity to obtain blood DNA samples for the Genome study in Montreal. In particular, we would like to thank Lee Pieterse for co-ordinating the project in Australia. She and her husband Frank also contributed $4000 towards the research. Sandy Smith in Canada, generously donated $8000 from the ‘For the Love of Ollie’ Fund. An additional sum of $4000 came from the ‘Syringomyelia DNA Research’ Fund. Total $16,000."